Endocrine Abstracts

Background: There is accumulating evidence suggesting that altered vitamin D may play a role in the development of T2DM. A growing body of evidence suggests that low levels of vitamin D may adversely affect the cardiovascular system.Objective: This is to assess the relation of serum 25 OH vitamin D concentrations and risk of CVD in T2DM patients.Subjects and methods: Seventy subjects aged from 40 to 60 years were chosen excluding t...

Background: Obesity is a common feature of women with PCOS in different ethnic cohorts. It is suggested that retinol binding protein 4 (RBP4) is a central mediator of obesity-induced insulin resistance in mice and humans. In addition, elevated serum RBP4 levels have been associated with cardiovascular risk factors and metabolic syndromes.Aim: To investigate whether serum RBP4 level is correlated with metabolic parameters, indices of insulin resistance, a...

Background: Type 2 diabetes (T2DM) represents an independent risk factor for cardiovascular diseases (CVD), being characterized by a continuous low-grade inflammation and endothelial activation state. Lipoprotein-associated phospholipase A2 (Lp-PLA2) may have a pro-inflammatory role as growing evidence suggests that it acts in several pathways that contribute to atherogenesis.Objective: The objective is to study Lp-PLA2 a...

Background: TSH surge is the most sensitive test currently available for confirming the diagnosis of central hypothyroidism, a hidden cause of idiopathic short stature.Objective: Studying the nocturnal TSH surge in children with the idiopathic shot stature.Patients and method: The study included 30 healthy children (10–18 years) as a control group and 30 children of matching age and sex with ISS as a patients group. TSH was me...

Background: Visceral fat-derived protein named visfatin was discovered in 2005. Visfatin may improve glucose tolerance, and its plasma levels correlate strongly with the amount of visceral adipose tissue in humans. Visfatin has insulin-like metabolic effects on glucose metabolism but has a distinct binding site on insulin receptors. These findings triggered great interest for many researchers to explore the mechanism(s) of regulation of visfatin expression, and the possible re...